The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painand to assess the long-term safety and effectiveness of this treatment for older adults.KEY WORDSPain in older adults: systematic review and meta-analysis of randomised trialsThis is the first systematic review and review of randomised controlled clinical trials addressing the efficacy and safety of corticosteroid injections as a treatment for musculoskeletal pain in older adults.MethodsWe extracted data from 26 systematic reviews of randomised controlled trials and 14 meta-analyses of randomised controlled trials.ParticipantsThree randomised controlled trials for musculoskeletal pain were included, testosterone propionate jak brac. Two used a mixed random effect-dummy design of the effect of treatment on outcomes in the groups assigned, while the third used a fixed effects-dummy design of the effect of treatment on outcomes only for the groups assigned. The effect of treatment on pain was assessed using the Cochrane Pain Rating Scale (CPRS). An effect size was calculated based on a random effect model of the treatment effect in each subgroup, testosterone propionate jak brac. We extracted data from two published articles for each randomised controlled trial with random numbers; five studies did not provide data; five studies reported results without random number estimation (n = 41; 14 studies for CCR, 5 studies for CPRS); and three studies reported results without random number estimation (n = 2, 2 studies for CCR); none of these data were shown for the two meta-analyses. Five studies provided individual data and their quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, testosterone propionate first cycle.ResultsTwenty-six studies met the inclusion criteria, athleticlightbody.com review. Ten of these studies had a random allocation concealment of allocation in the randomised controlled trials, and 14 did not account for randomisation in the meta-analyses, testosterone propionate vs cypionate. Of the 23 studies with randomisation concealment, we included 13 trials (nine with randomized controlled trials, two with mixed random effect-dummy designs). As in the rest of the systematic reviews and meta-analyses included in our review, we found that no differences were found between the effect of non-steroidal anti-inflammatory drug (NSAID) injections and corticosteroid injections in the meta-analysis, testosterone propionate trt dose.
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